Improvement of Drug-Loading Properties of Hydroxyapatite Particles Using Triethylamine as a Capping Agent: A Novel Approach

Particles that modify delivery characteristics are a focus of drug-loading research. Hydroxyapatite particles (HAPs) have excellent biocompatibility, shape controllability, and high adsorption, making them potential candidate for drug-delivery carriers. However, there still some defects in the current methods used to prepare HAPs. In order avoid agglomeration improve properties HAPs, present study provides novel triethylamine (TEA)-capped coprecipitation template method HAPs at room temperature. addition, pure water anhydrous ethanol were as solvents investigate capping effect small-molecule agent TEA during synthesis The results showed prepared system had smaller particle size (150–250 nm), better dispersion higher crystallinity. significantly different from those conventional preparation without TEA. hydroxyapatite crystal would agglomerate certain extent after being stored period time, forming micro/nano-sized agglomerates nanocrystals. FITR analysis SEM observation promoted formation dispersed quickly formed by dissolution reprecipitation processes. experiments capacity (239.8 ± 13.4 mg·g?1) well an improved drug-release profile demonstrated experiment. larger specific surface area associated with was beneficial adsorption drugs. After drying 60 °C, evaporated which agglomerated into micron more drug encapsulated. Thus, sustained release achieved. research, approach developed using HAP nanocrystals loading, is predicted application delivery.